|
KMID : 0525720110160030191
|
|
Journal of Chitin and Chitosan
2011 Volume.16 No. 3 p.191 ~ p.196
|
|
|
Percutaneous Absorption Characteristics for Karaya Gum and Locust Bean Gum/Chitosan Oligomer of Isocarboxazid as Antidepressants
|
|
Yoo Hyun-Oh
Kim Jong-Chul
Oh Eun-Ha
Im Ho-Sub
Na Jae-Sik
|
|
|
Abstract
|
|
|
Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Most common routes of administration include the preferred non-invasive peroral, topical(skin), transmucosal(nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Transdermal drug delivery offers many important advantages. For instance, it is easy and painless, it protects the active compound from gastric enzymes, and it avoids the hepatic first-pass effect. Also, it is simple to terminate the therapy if any adverse or undesired effect occurs. But skin is a natural barrier, and only a few drugs can penetrate the skin easily and in sufficient quantities to be effective. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other method of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharide, such as karaya gum and locust bean gum(LBG)/water-soluble chitosan oligomer(WSCO) were selected as base materials of TDS. Also, these polymers were
characterized in terms of enhancers, isocarboxazid contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in isocarboxazid such as lipophilic drug in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering isocarboxazid was found to be important in controlling the Percutaneous permeation rate.
|
|
|
KEYWORD
|
|
|
Antidepressant, Isocarboxazid, percutaneous absorption, MAO inhibitor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|